P53 is the gene most frequently mutated in cancers, but it is not the only pathology in which it may be involved, as recently shown by Prof. Franck Toledo’s group (Genetics of Tumor Suppression), with the collaboration of Dr. Arturo Londono – Vallejo’s group (Telomeres and cancer).
P53 is a well-known gene for cancer research laboratories. In 1979 , studies showed that it is frequently altered in various forms of cancer, and it was then quickly described as a tumor suppressor gene. These are genes that prevent cancer formation by triggering the death of damaged cells and avoiding their unregulated proliferation. Typically, the inactivation of these genes is what allows cancer cells to proliferate despite the presence of genetic errors.