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Antonin Morillon

Antonin Morillon
Speciality : Head and Principal Investigator, DR2 CNRS
Phone : +33 (0)1 56 24 65 70

Antonin MORILLON                            Curriculum Vitae

Education and Qualification

Directeur de recherche CNRS (DR2), CNRS (2010)

Habilitation to conduct research (PI diploma) HDR (2008)

Permanent CNRS position: CR1 (2004)

PhD: INAPG Paris 11 university (France) (2001)

Engineer Diploma: INSA Toulouse (France) (1996)

Master Degree Bachelor of Sciences (DEA): Univ. of Toulouse (France) (1996)

Professional experience

04/2010 Transfer of the group to the Curie Institut: “ncRNA, epigenetic and genome fluidity”. 8 people.

12/08-03/10 In charge of external seminars (invitation, financial supports and organization) at the Centre de Génétique Moléculaire (CGM CNRS, Gif sur Yvette).

10/06-03/10 In charge of the “Sterilization and Media” facility in the RNA Department (CGM, Gif sur Yvette).

10/05-03/10 Group Leader at CGM (CGM CNRS): “Chromatin and transcription, repression mechanisms”.

02/02-09/05 Post-doc, University of Oxford (Oxford, UK): "Chromatin remodelling in yeast" (Dr J. Mellor).

10/1997-10/01 PhD student, IBPC (Paris, France): "Transposition in yeast" (Dr M. Springer).

Grants

2010 - 2014 ERC starting grant

2009 - 2011 ANR “REGULncRNA”, coordinator of 4 groups

2006 - 2009 ATIP-CNRS

2006 - 2009 ANR (collaboration)

2006 ARC equipment funding

2006 FRM equipment funding

International Awards

2008 - 2011 EMBO Young Investigator Program award for current research activity

2005 - 2008 Human Frontier Science Program, Career Development Award, post-doc

2002 Nine Choucroun Prize, PhD

Publications

  1. van Dijk EL, Chen CL, d'Aubenton-Carafa Y, Gourvennec S, Kwapisz M, Roche V, Bertrand C, Silvain M, Legoix-Né P, Loeillet S, Nicolas A, Thermes C, Morillon A. (2011) XUTs are a class of Xrn1-sensitive antisense regulatory non-coding RNA in yeast. Nature. Jun 22;475(7354):114-7
  2. Cosnier B, Kwapisz M, Hatin I, Namy O, Hermann-Le Denmat S, Morillon A, Rousset JP, Fabret C. (2011) A viable hypomorphic allele of the essential IMP3 gene reveals novel protein functions in Saccharomyces cerevisiae. PLoS One. Apr 29;6(4):e19500.
  3. Clark MB, Amaral PP, Schlesinger FJ, Dinger ME, Taft RJ, Rinn JL, Ponting CP, Stadler PF, Morris KV, Morillon A, Rozowsky JS, Gerstein MB, Wahlestedt C, Hayashizaki Y, Carninci P, Gingeras TR, Mattick JS. (2011) The reality of pervasive transcription. PLoS Biol. Jul;9(7):e1000625 (review)
  4. Tisseur M, Kwapisz M, Morillon A. (2011) Pervasive transcription - Lessons from yeast. Biochimie. 93(11):1889-96 (review)
  5. Wery M, Kwapisz M, Morillon A. (2011) Noncoding RNAs in gene regulation. Wiley Interdiscip Rev Syst Biol Med. 2011 Nov;3(6):728-38 (review)
  6. Pinskaya M, Morillon A* (2009) H3K4 di methylation: a novel mark for transcriptional fidelity? Epigenetics, 4(5):302-6.
  7. Berretta J, Morillon A* (2009) Pervasive transcription a novel regulatory level in eukaryotes?" EMBO Reports 10(9):973-82.
  8. Pinskaya M, Gourvennec S, Morillon A* (2009) H3K4 di and tri-methylation deposited by cryptic transcription attenuates promoter activity. EMBO J. 28(12):1697-707.
  9. Pinskaya M, Nair A, Clynes D, Morillon A, Mellor J (2009) Nucleosome remodeling and transcriptional repression are distinct functions of Isw1 in Saccharomyces cerevisiae. Mol Cell Biol. 29(9):2419-30.
  10. Berretta J, Pinskaya M, Morillon A* (2008) A Cryptic Unstable Transcript mediates transcriptional trans-silencing of the Ty1 retrotransposon in S. cerevisiae. Genes and Dev. 22(5):615-26.
  11. Morillon A* (2006) Is nucleosome loss a common mechanism of DNA metabolism. Biochemistry of the Cell Biology  84(4):450-62.
  12. Morillon A, Karabetsou N, Nair A, Mellor J (2005) Differential lysine 4 methylation on histone H3 regulates RNA polymerase II. Mol Cell 18(6):723-34.
  13. Todescini AL, Morillon A Springer M and Lesage P (2005) Severe adenine starvation activates Ty1 transcription and retrotransposition in Saccharomyces cerevisiae. Mol Cell Biol. 25(17):7459-72.
  14. O'Sullivan JM*, Tan-Wong SM*, Morillon A*, Lee B, Coles J, Mellor J, Proudfoot NJ. (2004) Gene loops juxtapose promoters and terminators in yeast. Nat Genet. 36(9):1014-8. *coauthors
  15. Mellor J, Morillon A. (2004) ISWI complexes in Saccharomyces cerevisiae. Biochim Biophys Acta 1677(1-3):100-12.
  16. Santos-Rosa H, Schneider R, Bernstein B, Karabetsou N, Morillon A, Weise C, Schreiber S, Mellor J and Kouzarides T (2003) Methylation of histone H3 K4 mediates association of Isw1 ATPase with chromatin. Mol Cell 12;1325-1332.
  17. Morillon A, Karabetsou N, O’Sullivan J, Kent N, Proudfoot N, Mellor J (2003) Isw1 chromatin remodelling ATPase coordinates transcription elongation and termination by RNAPII. Cell 115(4):425-35.
  18. Morillon A, O’Sullivan J, Abdul A, Proudfoot N, Mellor J (2003) Regulation of elongating polymerase II by Forkhead transcription factors in yeast. Science  18(300):492-95.
  19. Morillon A, Bénard L, Springer M, Lesage P (2002) Differential effect of chromatin and Gcn4 on the Fifty-fold range of expression among individual yeast Ty1 retrotransposon. Mol Cell Biol. 22(7):2078-88.
  20. Morillon A, Springer M, Lesage P (2001) Strains isogenic to S288C used by the yeast genome sequencing program carry a functional KSS1 gene. Curr Genet. 5/6, 291-296.
  21. Morillon A, Springer M., Lesage P (2000) Activation of the invasive/filamentous growth pathway induces Ty1 transcription and retrotransposition in Saccharomyces cerevisiae. Mol Cell Biol 20(15):5766-76.
  22. Touriol C, Morillon A, Gensac MC, Prats H, Prats AC (1999) Expression of human fibroblast growth factor 2 mRNA is post-transcriptionally controlled by a unique destabilizing element present in the 3'-untranslated region between alternative polyadenylation sites. J Biol Chem. 274 (30):21402-8.